Surf Wiki
Save to docs
general/alpha-alkyltryptamines

From Surf Wiki (app.surf) — the open knowledge base

Α,N,N-Trimethyltryptamine

Psychoactive drug

Psychoactive drug

α,N,N-Trimethyltryptamine (α,N,N-TMT, α-TMT, or ATMT), also known as α-methyl-N,N-dimethyltryptamine (α-methyl-DMT or α-Me-DMT) or as Alpha-N, is a psychedelic drug of the tryptamine and α-alkyltryptamine families. It is similar in chemical structure to other psychedelic tryptamines such as N,N-dimethyltryptamine (DMT) and α-methyltryptamine (αMT). It is taken orally.

Use and effects

α,N,N-TMT was briefly mentioned by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved), but he did not mention having tested it and did not describe its effects, dose, or duration. In 2025, Hamilton Morris described having synthesized and assayed α,N,N-TMT. He reported that it was an active psychedelic taken orally but was much less potent than AMT.

Interactions

Pharmacology

Pharmacodynamics

The drug has been tested in animals and compared with α-methyltryptamine (αMT). It was found to produce similar effects as αMT, such as hyperlocomotion and reversal of reserpine-induced behavioral depression, but with only around half the potency of αMT.

Chemistry

Analogues

Analogues of α,N,N-TMT (N,N-dimethyl-AMT) include α-methyltryptamine (AMT), α,N-DMT (N-methyl-AMT), α-methylserotonin (AMS; 5-HO-AMT), 5-MeO-AMT (α,O-DMS), α,N,O-TMS (N-methyl-5-MeO-AMT), and α,N,N,O-TeMS (N,N-dimethyl-5-MeO-AMT), among others.

History

α,N,N-TMT was encountered as a novel designer drug in Europe by 2015.

Society and culture

Canada

α,N,N-TMT is not an explicitly nor implicitly controlled substance in Canada as of 2025.

United States

α,N,N-TMT is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

References

References

  1. (1997). "[[TiHKAL: The Continuation]]". Transform Press.
  2. (May 1966). "Synthesis and pharmacological activity of alkylated tryptamines". Journal of Medicinal Chemistry.
  3. (29 April 2025). "POD 126: The Return of Psychedelic Selenium with Dr. Josh Hartsel". Patreon.
  4. (23 October 2018). "2015 Annual Reports on the implementation of Council Decision 2005/387/JHA".
  5. (5 December 2025). "Controlled Drugs and Substances Act".
  6. (January 2026). "Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026)". U.S. [[Department of Justice]]: [[Drug Enforcement Administration]] (DEA): Diversion Control Division.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

alpha-alkyltryptamines designer-drugs n,n-dialkyltryptamines dimethylamino-compounds hamilton-morris psychedelic-tryptamines
Want to explore this topic further?

Ask Mako anything about Α,N,N-Trimethyltryptamine — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report