7,N,N-TMT

Use and effects

7-Methyl-DMT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).

Interactions

Pharmacology

Pharmacodynamics

7-TMT acts as an agonist of 5-HT2 receptors. In animal tests, both 7-TMT and its 5-methoxy derivative 5-MeO-7-TMT produced behavioural responses similar to those of psychedelic drugs such as DMT, but the larger 7-ethyl and 7-bromo derivatives of DMT did not produce psychedelic responses despite having higher 5-HT2 receptor affinity in vitro (cf. DOBU, DOAM). 7-TMT also weakly inhibits reuptake of serotonin but with little effect on dopamine or noradrenaline reuptake.

Chemistry

Synthesis

The chemical synthesis of 7,N,N-TMT has been described.

Analogues

Analogues of 7-methyl-DMT include dimethyltryptamine (DMT), 5-MeO-7-TMT (5-MeO-7,N,N-TMT), 7-MeO-DMT, 7-hydroxy-DMT, 7-methyl-AET, 7-MeO-DiPT, 7-MeO-MiPT, 7-chloro-AMT, 1-methyl-DMT, 2-methyl-DMT, 4-methyl-DMT, 5-methyl-DMT, and 6-methyl-DMT, among others.

History

7,N,N-TMT was first described in the scientific literature by Richard Glennon and colleagues by 1978. It was encountered online as a novel designer drug in 2024.

References

References

1. (August 1978). "Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues". Journal of Medicinal Chemistry.
2. (April 1979). "Serotonin receptor binding affinities of tryptamine analogues". Journal of Medicinal Chemistry.
3. (January 1988). "Indolealkylamine analogs share 5-HT2 binding characteristics with phenylalkylamine hallucinogens". European Journal of Pharmacology.
4. "7-Me-DMT (7-TMT)".
5. {{CiteTiHKAL
6. (November 1980). "Studies on several 7-substituted N,N-dimethyltryptamines". Journal of Medicinal Chemistry.
7. (January 1978). "7,N,N-Trimethyltryptamine: a selective inhibitor of synaptosomal serotonin uptake". Research Communications in Chemical Pathology and Pharmacology.