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6-CAT

Chemical compound

Chemical compound

6-Chloro-2-aminotetralin (6-CAT) is a drug which acts as a selective serotonin releasing agent (SSRA) and is a putative entactogen in humans. It is a rigid analogue of para-chloroamphetamine (PCA).

According to Nichols et al., 6-CAT is a non-neurotoxic analog of PCA.

Other related compounds that are creditworthy of mention include 6,7-DCAT & 5,6-DCAT [57915-89-6]. The compound depicted in the latter case is with the spirodecanone pharmacophore.

It is worth pointing out that the precursor used in the synthesis of 6-CAT is called 6-Chloro-2-tetralone [17556-18-2]. This compound is actually the starting material in the synthesis of Bexlosteride.

References

References

  1. (November 1974). "6-Chloro-2-aminotetralin, a rigid Conformational analog of 4-chloroamphetamine: pharmacologic properties of it and related compounds in rats". Archives Internationales de Pharmacodynamie et de Therapie.
  2. (1977). "Comparison of the effects of 6-chloro-2-aminotetralin and of ORG 6582, a related chloroamphetamine analog, on brain serotonin metabolism in rats". Biochemical Pharmacology.
  3. (May 1991). "Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: similarities to 3,4-(methylenedioxy)methamphetamine (MDMA)". Journal of Medicinal Chemistry.
  4. Bryan B Molloy, {{US patent. 3919316 (1975 to Eli Lilly and Co).
  5. (6 April 2000). "High-Affinity, Non-Peptide Agonists for the ORL1 (Orphanin FQ/Nociceptin) Receptor". Journal of Medicinal Chemistry.
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2-aminotetralins entactogens chloroarenes serotonin-releasing-agents
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