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5-Methyluridine

One of the five major nucleosides in nucleic acids

One of the five major nucleosides in nucleic acids

The chemical compound 5-methyluridine (symbol m5U), also called ribothymidine (rT), is a pyrimidine nucleoside. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar.{{cite journal|title=Catalytic crosslinking-based methods for enzyme-specified profiling of RNAribonucleotide modifications|author=Shobbir Hussain|journal=Methods|volume=156|year=2019|pages=60–65 | doi=10.1016/j.ymeth.2018.10.003|pmid=30308313 |s2cid=52961265 |url=https://researchportal.bath.ac.uk/en/publications/5a05dcf5-c4df-4344-bc70-7877c5ef08bf}} It is a white solid.

m5U is one of the most common modifications made to cellular RNA. It almost universally occurs in position 54 (part of the T arm) of eukaryotic and bacterial tRNA, serving to stabilize the molecule. The same "T-loop" motif occurs in many other forms of noncoding RNA such as tmRNA and rRNA. Loss of the tRNA modification does not usually produce a different, less fit, phenotype.

Footnotes

References

References

  1. "5-Methyluridine".
  2. William M. Haynes. (2016). "CRC Handbook of Chemistry and Physics". CRC Press.
  3. (2013). "Lehninger Principles of Biochemistry". [[W. H. Freeman and Company]].
  4. (April 2020). "TRMT2B is responsible for both tRNA and rRNA m(5)U-methylation in human mitochondria.". RNA Biology.
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nucleosides pyrimidinediones
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