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5-Methyl-MDA

Chemical compound

Chemical compound

| elimination_half-life = 204916-89-2 (HCl)

5-Methyl-MDA, also known as 5-methyl-3,4-methylenedioxyamphetamine, is an entactogen and psychedelic designer drug of the amphetamine class. It is a ring-methylated homologue of MDA and a structural isomer of MDMA.

Pharmacology

5-Methyl-MDA acts as a selective serotonin releasing agent (SSRA) with IC50 values of 107nM, 11,600nM, and 1,494nM for serotonin, dopamine, and norepinephrine release, respectively.

2-methyl-MDA and 5-methyl-MDA have been used to help guide computer modelling of the serotonin transporter complex.

Society and culture

International

5-Methyl-MDA is not scheduled by the United Nations' Convention on Psychotropic Substances.

Canada

As per the Safe Streets and Communities Act, 5-methyl-MDA, along with all other amphetamines, is a Schedule I controlled substance under the Controlled Drugs and Substances Act.

United States

5-Methyl-MDA is not explicitly scheduled at the federal level in the United States, however 5-Methyl-MDA is a structural isomer of MDMA, and so sales or possession could potentially be prosecuted under the Federal Analogue Act.

References

References

  1. (March 1998). "Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA)". Journal of Medicinal Chemistry.
  2. (June 2008). "Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition". The Journal of Pharmacology and Experimental Therapeutics.
  3. "Convention on Psychotropic Substances, 1971".
  4. "§1308.11 Schedule I.".
  5. [https://www.erowid.org/psychoactives/law/analog/analog_info1.shtml Erowid Analog Law Vault : Federal Controlled Substance Analogue Act Summary]
Info: Wikipedia Source

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designer-drugs entactogens methylenedioxyphenethylamines psychedelic-phenethylamines serotonin-releasing-agents substituted-amphetamines
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