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4-HO-MPMI

Chemical compound

Chemical compound

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4-HO-MPMI, also known as 4-hydroxy-N-methyl-(α,N-trimethylene)tryptamine or as lucigenol, is a psychedelic drug of the pyrrolidinylmethylindole and cyclized tryptamine families.

Interactions

Pharmacology

Pharmacodynamics

The affinity (Ki) of 4-HO-MPMI for the serotonin 5-HT2A receptor has been found to be 13nM. It produces psychedelic-appropriate responding in animal tests with similar potency as DOI. The drug has two enantiomers, with only the (R)-enantiomer being active.

Chemistry

Analogues

Analogues of 4-HO-MPMI include MPMI, 5-MeO-MPMI, 5F-MPMI, CP-135,807, 4-HO-McPeT, 4-HO-pyr-T, and SN-22, among others.

History

4-HO-MPMI was developed by the team led by David E. Nichols from Purdue University in the late 1990s.

Society and culture

Canada

4-HO-MPMI is not a controlled substance in Canada as of 2025.

References

References

  1. (1999). "Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain". Journal of Medicinal Chemistry.
  2. "Controlled Drugs and Substances Act".
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alpha-alkyltryptamines david-e.-nichols designer-drugs n,n-dialkyltryptamines 4-hydroxytryptamines pyrrolidinylmethylindoles psychedelic-tryptamines
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