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4-Aminoquinoline

4-Aminoquinoline is a form of aminoquinoline with the amino group at the 4-position of the quinoline. The compound has been used as a precursor for the synthesis of its derivatives.

A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. Examples include amodiaquine, chloroquine, and hydroxychloroquine. Other uses for the derivatives are: anti-asthmatic, antibacterial, anti-fungal, anti-malarial, antiviral and anti-inflammatory agents.

A patent application for 4-aminoquinoline compounds was filed in 2002 and published in 2005.

Image:Amodiaquine.svg|Amodiaquine Image:Chloroquine.svg|Chloroquine Image:Hydroxychloroquine.svg|Hydroxychloroquine

References

References

  1. (2016-08-01). "Synthesis, spectroscopic and DFT theoretical studies on the hydrogen bonded charge transfer complex of 4-aminoquinoline with chloranilic acid". Journal of Molecular Liquids.
  2. (2019-08-01). "Structural aspects of 4-aminoquinolines as reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase". Chemico-Biological Interactions.
  3. (1996). "4-Aminoquinoline resistance of Plasmodium falciparum: insights from the study of amodiaquine uptake". Mol. Pharmacol..
  4. (13 January 2005). "4-Aminoquinoline Compounds". United States Patent Application Publication.
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