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3-Iodotyrosine

3-Iodotyrosine is an intermediate in the synthesis of thyroid hormones which is derived from iodination of tyrosine at the meta-position of the benzene ring. One unit can combine with diiodotyrosine to form triiodothyronine, as occurs in the colloid of the thyroid follicle. Two units can combine to form 3,3'-diiodothyronine.

3-Iodotyrosine is a reversible inhibitor of the enzyme tyrosine hydroxylase.

Relevance in dopamine studies

3-Iodotyrosine, a pathway inhibitor in the synthesis of the neurotransmitter dopamine, was used to determine the effects of decreased dopamine levels in social spacing of Drosophila melanogaster. 3-4 day old flies that were fed 3-iodotyrosine for 24 hours were shown to have altered dopamine levels.

References

(March 1989). "Carrier-mediated transport of monoiodotyrosine out of thyroid cell lysosomes". J. Biol. Chem..
Richelson E. (November 1976). "Properties of tyrosine hydroxylation in living mouse neuroblastoma clone N1E-115". Journal of Neurochemistry.
(2017-08-01). "Modulation of social space by dopamine in Drosophila melanogaster, but no effect on the avoidance of the Drosophila stress odorant". Biology Letters.

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iodinated-tyrosine-derivatives tyrosine-hydroxylase-inhibitors

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