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general/3-aminopyridines

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3-Aminopyridine


3-Aminopyridine is an aminopyridine. It is a colorless solid.

Preparation

3-Aminopyridine is prepared by heating nicotinamide with sodium hypobromite (Hofmann rearrangement), which is in turn prepared in situ by the reaction of sodium hydroxide and bromine at 70 °C.

:[[File:Synthesis of 3-Aminopyridine.gif]]

It can be used in the synthesis of organic ligand 3-pyridylnicotinamide. Troxipide is another synthesis that uses 3-AP.

Toxicity

The acute toxicity is indicated by the = 178 mg/kg (quail, oral).

References

References

  1. (1950). "3-Aminopyridine".
  2. (2000). "Pyridine and Pyridine Derivatives".
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