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general/methylenedioxyphenethylamines

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3,4-Methylenedioxyphentermine

Chemical compound

Chemical compound

FieldValue
Verifiedfieldschanged
Watchedfieldschanged
verifiedrevid424870031
drug_nameMDPH
imageMethylenedioxyphentermine.svg
image_classskin-invert-image
width225px
routes_of_administrationOral
classPsychoactive drug
ATC_prefixNone
duration_of_action3–5 hours
CAS_number_Ref
CAS_number39235-63-7
PubChem13020598
ChemSpiderID_Ref
ChemSpiderID15204207
UNIIWF9K2PM8J8
ChEMBL126226
synonymsMDP; MDPH; 3,4-Methylenedioxyphentermine; 3,4-Methylenedioxy-α,α-dimethylphenethylamine
IUPAC_name1-(2H-1,3-benzodioxol-5-yl)-2-methylpropan-2-amine
C11H=15N=1O=2
SMILESNC(C)(C)CC1=CC(OCO2)=C2C=C1
StdInChI_Ref
StdInChI1S/C11H15NO2/c1-11(2,12)6-8-3-4-9-10(5-8)14-7-13-9/h3-5H,6-7,12H2,1-2H3
StdInChIKey_Ref
StdInChIKeyOIZBHKBNZXRXSM-UHFFFAOYSA-N

| Drugs.com =

| elimination_half-life =

3,4-Methylenedioxyphentermine (MDPH) is a psychoactive drug of the amphetamine family. MDPH was first synthesized by Alexander Shulgin. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPH.

Use and effects

In his book PiHKAL (Phenethylamines i Have Known And Loved), the dose range is listed as 160–240 mg, and the duration as 3 to 5hours. MDPH's effects are very similar to those of MDA: they both are smooth and "stoning," and do not cause any visuals. They also alter dreams and dream patterns. But it is said to have none of the magic of MDMA. Shulgin describes MDPH as a promoter; it promotes the effects of other drugs, similarly to 2C-D.

Chemistry

Synthesis

The chemical synthesis of MDPH has been described.

Analogues

The N-methyl derivative, 3,4-methylenedioxy-N-methylphentermine (MDMPH), has been described by Shulgin as lacking MDMA-like effects. Accordingly, MDMPH, as well as MDPH, were found to be inactive as serotonin releasing agents in vitro.

Society and culture

United Kingdom

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.

References

References

  1. {{CitePiHKAL [http://www.erowid.org/library/books_online/pihkal/pihkal116.shtml MDPH entry in ''PiHKAL'']
  2. (1990). "Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA". Springer US.
  3. (May 1982). "Effects of certain hallucinogenic amphetamine analogues on the release of [3H]serotonin from rat brain synaptosomes". Journal of Medicinal Chemistry.
  4. "UK Misuse of Drugs act 2001 Amendment summary". Isomer Design.
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