2C-T

Use and effects

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists 2C-T's dose range as 60 to 100mg orally and its duration as 3 to 5hours. Its onset is described as 15minutes and its effects are said to develop "very quickly but very quietly". It is one of the shortest-acting of the 2C psychedelics as well as among the least potent.

The effects of 2C-T have been reported to include being "really psychedelic", little or nothing in the way of psychedelic visuals, some fantasy with music, increased appreciation of poetry, things feeling "opened up" like with MDMA, being a possible MDMA substitute in this regard, feeling somewhat "generic" as a psychedelic, intellectual thinking overpowering emotions, conversational facilitation, tactile enhancement, enhanced eroticism, and stomach discomfort.

Interactions

Pharmacology

Pharmacodynamics

2C-T shows affinity for the serotonin 5-HT2 receptors and is known to act as an agonist of the serotonin 5-HT2A and 5-HT2B receptors. The drug shows no affinity for the monoamine transporters.

Chemistry

2C-T is in a class of compounds commonly known as phenethylamines, and is the 4-methylthio analogue of 2C-O, a positional isomer of mescaline. It is also the 2C analog of Aleph. The systematic name of the chemical is 2-(2,5-dimethoxy-4-(methylthio)phenyl)ethanamine. The CAS number of 2C-T is 61638-09-3.

Synthesis

The chemical synthesis of 2C-T has been described.

Derivatives

A large number of derivatives of 2C-T have been developed and described. These include 2C-T-2, 2C-T-3, 2C-T-4, 2C-T-7, 2C-T-21, and CYB-210010 (2C-T-TFM or 2C-T-36), among many others.

History

2C-T was first synthesized and studied through a collaboration between David E. Nichols and Alexander Shulgin. It was first described in the scientific literature in 1976. The drug was encountered as a novel designer drug in Europe in 2023.

Society and culture

Legal status

Canada

As of October 31, 2016; 2C-T is a controlled substance (Schedule III) in Canada.

United States

2C-T is unscheduled and unregulated in the United States; however its close similarity in structure and effects to 2C-T-7 could potentially subject possession and sale of 2C-T to prosecution under the Federal Analog Act. This seems to be the tack the federal government is taking in the wake of the DEA's Operation Web Tryp. A series of court cases in the US involving the prosecution of several online vendors were commenced in 2004 and resulted in a number of convictions.

References

References

1. (2011). "[[The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds]]". [[Transform Press]].
2. "2C-T".
3. {{CitePiHKAL [http://www.erowid.org/library/books_online/pihkal/pihkal039.shtml 2C-T Entry in PiHKAL]
4. (May 2018). "Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)". Neuropharmacology.
5. (August 2023). "Structure-Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists". ACS Chem Neurosci.
6. (October 1976). "Sulfur analogs of psychotomimetic amines". Journal of Pharmaceutical Sciences.
7. (4 May 2016). "Regulations Amending the Food and Drug Regulations (Part J — 2C-phenethylamines)". Canada Gazette.
8. (July 22, 2004). "DEA Announces Arrests and Investigation". Erowid Psychoactive Vaults : Research Chemicals.