followed by a championship game

The 2010 Conference USA baseball tournament was the 2010 postseason college baseball championship of the NCAA Division I Conference USA, held at Cougar Field in Houston, Texas, from May 26–May 30, 2010. Southern Miss won the tournament and received Conference USA's automatic bid to the 2010 NCAA Division I baseball tournament.

The tournament format changed from that which had been used since the 2000 tournament. It consisted of six teams split into two three-team pods. Each team played a total of three preliminary games, two against its podmates and one against a team from the opposite pod. The team with the best record in each pod going advanced to a single-game final.

Bracket

	team2=MRSH	team3=HOU	result1=F	loss_RICE=0	gf_RICE=53	ga_RICE=6	loss_MRSH=2	gf_MRSH=17	ga_MRSH=36	loss_HOU=2	gf_HOU=20	ga_HOU=41	year=2010	team=Rice Owls	title=Rice}}	year=2010	team=Marshall Thundering Herd	title=Marshall}}	year=2010	team=Houston Cougars	title=Houston}}	res_col_header=Q	text_F=Advance to Finals		team2=MEM	team3=ECU	result1=F	loss_USM=1	gf_USM=19	ga_USM=16	loss_MEM=2	gf_MEM=12	ga_MEM=20	loss_ECU=2	gf_ECU=13	ga_ECU=15	year=2010	team=Southern Miss Golden Eagles	title=Southern Miss}}	year=2010	team=Memphis Tigers	title=Memphis}}	year=2010	team=East Carolina Pirates	title=East Carolina}}	res_col_header=Q	text_F=Advance to Finals

| RD1-team1 = Rice | RD1-score1 = 4 | RD1-team2 = Southern Miss | RD1-score2 = 7