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2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Class of enzymes
Class of enzymes
| Field | Value |
|---|---|
| Symbol | OHCU_decarbox |
| Name | OHCU decarboxylase |
| caption | structure of ohcu decarboxylase from zebrafish |
| Pfam | PF09349 |
| InterPro | IPR018020 |
In molecular biology 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) is an enzyme involved in purine catabolism. It catalyses the decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) into S(+)-allantoin. It is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase and step two is catalysed by hydroxyisourate hydrolase.
References
References
- (March 2006). "Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes". Nat. Chem. Biol..
- (2007). "The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation.". J Biol Chem.
- (2007). "Structural and functional basis for (S)-allantoin formation in the ureide pathway.". J Biol Chem.
- (2006). "Update on ureide degradation in legumes.". J Exp Bot.
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