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2-Nitropropane

39 °C (closed cup) | NFPA-H = 3 | NFPA-R = 2 | NFPA-F = 3 400 ppm (rat, 6 hr) 2381 ppm (rabbit, 5 hr) 4622 ppm (guinea pig, 5 hr) 2353 ppm (cat, 1 hr)

2-Nitropropane (2-NP) is an organic compound with the formula . It is used as a solvent. It is a colorless liquid and is classified as a nitro compound.

Preparation

2-Nitropropane is produced by the high-temperature vapor-phase nitration of propane, usually with impurities of 1-nitropropane. 2-Nitropropane is also produced as a volatile by-product that can be captured during Leonard's ring-closure hydantoin preparation.

Uses

2-Nitropropane is used as a solvent or additive in inks, paints, adhesives, varnishes, polymers, resins, fuel, and coatings. It is also used as a feedstock for other industrial chemicals, and also in the synthesis of pharmaceuticals such as phentermine, chlorphentermine, and teclozan. It serves as an oxidant in the Hass–Bender oxidation process.

Safety

2-Nitropropane is a constituent of tobacco smoke. Based on studies in animals, it is reasonably anticipated to be a human carcinogen

References

References

  1. {{GESTIS
  2. {{PGCH. 0460
  3. {{IDLH. 79469. 2-Nitropropane
  4. {{ cite encyclopedia. Markofsky, S. B.. (2000). Wiley-VCH
  5. (6 Mar 2014). "Alternative synthesis of the anti-baldness compound RU58841". RSC Advances.
  6. (2011). "Report on Carcinogens". [[National Toxicology Program]], [[Department of Health and Human Services]].
  7. (2011). "Hazardous Compounds in Tobacco Smoke". International Journal of Environmental Research and Public Health.
  8. "Agents Classified by the IARC Monographs".
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nitroalkanes nitro-solvents isopropyl-compounds
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