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2-Hydroxymuconate-6-semialdehyde dehydrogenase

Class of enzymes


Class of enzymes

FieldValue
Name2-Hydroxymuconate-6-semialdehyde dehydrogenase
EC_number1.2.1.85

2-Hydroxymuconate-6-semialdehyde dehydrogenase (, * [gene], * [gene] ) is an enzyme with systematic name (2E,4Z)-2-hydroxy-6-oxohexa-2,4-dienoate:NAD+ oxidoreductase. This enzyme catalyses the following chemical reaction

This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds.

References

References

  1. (March 1995). "Overlapping substrate specificities of benzaldehyde dehydrogenase (the xylC gene product) and 2-hydroxymuconic semialdehyde dehydrogenase (the xylG gene product) encoded by TOL plasmid pWW0 of Pseudomonas putida". Journal of Bacteriology.
  2. (November 2006). "Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain 10d: A different modified meta-cleavage pathway for 2-aminophenols". Bioscience, Biotechnology, and Biochemistry.
  3. (November 2009). "Uncovering the protocatechuate 2,3-cleavage pathway genes". Journal of Bacteriology.
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