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2-Chloroethyl chloroformate

2-Chloroethyl chloroformate (chemical formula: C3H4Cl2O2) has a structure consisting of ethyl chloroformate with a chloro group as substituent on the ethyl group.

Synthesis

2-Chloroethyl chloroformate is the sole product of the reaction between ethylene oxide and phosgene in the presence of a small amount of pyridine.

Uses

2-Chloroethyl chloroformate is commonly used as a reagent, especially for making derivatives of amines and carboxylic acids for analysis by gas chromatography.

References

References

  1. "Safety data sheet: 2-chloroethyl chloroformate".
  2. (1957). "530. The reaction of carbonyl chloride with 1 : 2-epoxides". Journal of the Chemical Society (Resumed).
  3. (2011). "Encyclopedia of Reagents for Organic Synthesis".
  4. Wu, Yikang. (2000). "A high-yielding low-cost facile synthesis of 2-oxazolidinones chiral auxiliaries". Tetrahedron: Asymmetry.
  5. (1992). "The derivatization of fatty acids by (Chloro)alkyl chloroformates in non-aqueous and aqueous media for GC analysis". Journal of High Resolution Chromatography.
  6. (1998). "Chloroformates in gas chromatography as general purpose derivatizing agents". Journal of Chromatography B: Biomedical Sciences and Applications.
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chloroformates chloroethyl-compounds
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