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2-Amino-4-deoxychorismate dehydrogenase

Class of enzymes

Field	Value
Name	2-amino-4-deoxychorismate dehydrogenase
EC_number	1.3.8.16

2-Amino-4-deoxychorismate dehydrogenase (, ADIC dehydrogenase, 2-amino-2-deoxyisochorismate dehydrogenase, SgcG) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase. This enzyme catalyses the following chemical reaction

It converts 2-amino-2-deoxyisochorismic acid (1) into 3-(1-carboxyvinyloxy)anthranilic acid (2) by oxidation using flavin mononucleotide (FMN) as its cofactor.

Antibiotic C-1027

This reaction is part of the biosynthesis of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 from Streptomyces globisporus. The intermediate acid (1) is produced from chorismic acid by the enzyme 2-amino-4-deoxychorismate synthase:

References

(January 2008). "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism". Proceedings of the National Academy of Sciences of the United States of America.
(1995). "The benzoxazolinate of C-1027 confers intercalative DNA binding". J. Am. Chem. Soc..
{{KEGG enzyme. 1.3.99.24

Info: Wikipedia Source

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ec-1.3.8

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