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2-Acetylpyridine

1-(2-Pyridinyl)ethanone Methyl 2-pyridyl ketone

2-Acetylpyridine is an organic compound with the formula . It is a viscous colorless liquid that is widely used as a flavoring substance. It is found in malt and produced by the Maillard reaction and by nixtamalization. It contributes to the flavor of corn tortillas, popcorn, and beer.

Synthesis

The compound is prepared by acylation of 2-bromopyridine via the Grignard reagent.

Chemical Use

  • Synthesis of Doxylamine.

References

References

  1. [http://www.sigmaaldrich.com/catalog/product/ALDRICH/W325104 Sigma Adrich]
  2. [http://www.chemicalbook.com/ChemicalProductProperty_US_CB7131206.aspx ChemicalBook]
  3. National Toxicology Program[https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/chem_background/exsumpdf/2-acetylpyridine_508.pdf "Summary of Data for Chemical Selection"]
  4. Trécourt, F.; Breton, G.; Bonnet, V.; Mongin, F.; Marsais, F.; Quéguiner, G., "New Syntheses of Substituted Pyridines via Bromine–Magnesium Exchange", Tetrahedron 2000, volume 56, pp. 1349-1360. {{doi. 10.1016/S0040-4020(00)00027-2.
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2-pyridyl-compounds aromatic-ketones
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