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2,5-Xylidine
2,5-Xylidine is an organic compound with the formula C6H3(CH3)2NH2. It is one of several isomeric xylidines. It is a colorless viscous liquid. Commercially significant derivatives include Solvent Yellow 30, Solvent Red 22, Acid Red 65, and Solvent Red 26. :[[Image:Solvent Red 26.png|thumb|left|Solvent Red 26 is a commercial dye prepared from 2,5-xylidine]]
Production
Like many xylidines, it is prepared by nitration of the corresponding xylene followed by reduction of the nitroxylene. Reduction can be effected with HCl/Fe, but usually is achieved by catalytic hydrogenation: :Me2C6H4 + HNO3 → Me2C6H3NO2 + H2O :Me2C6H3NO2 + 3 H2 → Me2C6H3NH2 + 3H2O
Safety
It is mutagenic and tumor-inducing. Acute toxicity of xylidines is modest as indicated by LD50 (rats, oral) are in the range 0.1-1 g/kg.
References
References
- M. Meyer. (2012). "Xylidines". Wiley-VCH.
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