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2,3,4,5-Tetramethoxyamphetamine

Chemical compound

Chemical compound

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Tetramethoxyamphetamine (TeMA), or 2,3,4,5-tetramethoxyamphetamine (2,3,4,5-TeMA), also known as 2-methoxy-TMA or 3-methoxy-TMA-2, is a drug of the phenethylamine and amphetamine families related to mescaline (3,4,5-trimethoxyphenethylamine).

In Alexander Shulgin's book PiHKAL (Phenethylamines I Have Known And Loved), the minimum dose is listed as 50mg, and the duration as unknown but has been said to be relatively long-lived. TeMA is said to produce a threshold, disinhibited intoxication, mydriasis, and a headache. It is said to be roughly 6times as potent as mescaline.

TeMA has been said to be the only amphetamine with more than three methoxy groups known to be hallucinogenic. However, subsequently, the psychedelic properties of TeMA were questioned. Limited data exists about its pharmacological properties, metabolism, and toxicity. It was first described in the scientific literature by at least 1975. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.

References

References

  1. {{CitePiHKAL
  2. (1975). "Hallucinogenic Agents". Wright-Scientechnica.
  3. (1978). "Stimulants". Springer US.
  4. (1994). "Amphetamine and Its Analogs: Psychopharmacology, Toxicology, and Abuse". Academic Press.
  5. (December 1977). "Structure-activity studies on hallucinogenic amphetamines using molecular connectivity". Journal of Medicinal Chemistry.
  6. (February 1990). "Structure-activity correlations for psychotomimetics. 1. Phenylalkylamines: electronic, volume, and hydrophobicity parameters". Journal of Medicinal Chemistry.
  7. (September 1998). "The frontier orbital phase angles: novel QSAR descriptors for benzene derivatives, applied to phenylalkylamine hallucinogens". Journal of Medicinal Chemistry.
  8. "Controlled Drugs and Substances Act".
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dox-(psychedelics) methoxyphenethylamines pihkal
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