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1-Pyrroline-5-carboxylate dehydrogenase

Class of enzymes

Class of enzymes

FieldValue
Name1-pyrroline-5-carboxylate dehydrogenase
EC_number1.2.1.88
CAS_number9054-82-4
GO_code0003842

In enzymology, a 1-pyrroline-5-carboxylate dehydrogenase () is an enzyme that catalyzes the chemical reaction

: (S)-1-pyrroline-5-carboxylate + NAD+ + 2 H2O \rightleftharpoons L-glutamate + NADH + H+

The three substrates of this enzyme are (S)-1-pyrroline-5-carboxylate, NAD+, and H2O, whereas its three products are glutamate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase. Other names in common use include delta-1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, and 1-pyrroline-5-carboxylate:NAD+ oxidoreductase. This enzyme participates in glutamate metabolism and arginine and proline metabolism.

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , and .

Human gene

In human, the protein is encoded by ALDH4A1 gene.

References

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-1.2.1 oxidoreductases
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