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1-Octacosanol

28-carbon primary fatty alcohol

28-carbon primary fatty alcohol

1-Octacosanol (also known as n-octacosanol, octacosyl alcohol, cluytyl alcohol, montanyl alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is common in the epicuticular waxes of plants, including the leaves of many species of Eucalyptus, of most forage and cereal grasses, of Acacia, Trifolium, Pisum and many other legume genera among many others, sometimes as the major wax constituent. Octacosanol also occurs in wheat germ.{{cite web |url-status=live

Chemistry

Octacosanol is insoluble in water but freely soluble in low molecular-weight alkanes and in chloroform.

Biological effects

Octacosanol is the main component in the mixture policosanol. Octacosanol has been subject to preliminary study for its potential benefit for patients with Parkinson's disease. Studies have also found that octacosanol may inhibit the production of cholesterol. In mice, octacosanol reduces stress and restores stress-affected sleep back to normal.

References

References

  1. EA Baker (1982) Chemistry and morphology of plant epicuticular waxes. pp. 139–165. ''In'' "The Plant Cuticle". edited by DF Cutler, KL Alvin and CE Price. Academic Press, London. {{ISBN. 0-12-199920-3
  2. (2003). "Octacosanol in human health". Nutrition.
  3. (1984). "Octacosanol in parkinsonism". Annals of Neurology.
  4. (2010). "Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling". Acta Pharmacologica Sinica.
  5. (21 August 2017). "Octacosanol restores stress-affected sleep in mice by alleviating stress". Scientific Reports.
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fatty-alcohols primary-alcohols alkanols
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