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1-(2-Diphenyl)piperazine

Chemical compound

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1-(2-Diphenyl)piperazine, also known as RA-7, is a drug that acts as a potent and selective antagonist at the 5HT serotonin receptor. It was discovered as an active metabolite of the synthetic 5-HT agonists LP-12 and LP-211 and unexpectedly turned out to be a potent antagonist with selectivity approaching that of the parent molecules, despite its much simpler structure.

References

(August 2010). "LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor". Neuroscience Letters.

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serotonin-receptor-agonists phenylpiperazines 1-piperazinyl-compounds

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