Surf Wiki
Save to docs
general/chloroalkanes

From Surf Wiki (app.surf) — the open knowledge base

1,2-Dichloropropane

| NFPA-H = 2 | NFPA-F = 3 | NFPA-R = 0 720 ppm (mouse, 10 hr) 2980 ppm (rat, 8 hr) 1947 mg/kg (rat, oral) 2000 mg/kg (guinea pig, oral)

1,2-Dichloropropane is an organic compound classified as a chlorocarbon. It is a colorless, flammable liquid with a sweet odor. it is obtained as a byproduct of the production of epichlorohydrin, which is produced on a large scale.

Uses

1,2-Dichloropropane is an intermediate in the production of perchloroethylene and other chlorinated chemicals.

Carcinogenity

Following several cases of bile duct cancer among Japanese printing firm employees, an investigation by the Japanese Ministry of Health, Labour and Welfare concluded in March 2013 that these cases were likely due to the use of cleaning agents containing 1,2-dichloropropane. Thus, there is reasonable evidence that 1,2-dichloropropane may be a carcinogen.

Data from animal studies show tumor growth in the liver and mammary glands. Further animal studies involving inhalation toxicity data has caused the National Institute for Occupational Safety and Health to classify 1,2-dichloropropane as a carcinogen and IDLH.

References

category:halogenated solvents

References

  1. [http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO|BRAND_KEY&N4=D72182|ALDRICH&N25=0&QS=ON&F=SPEC 1,2-Dichloropropane] at [[Sigma-Aldrich]]
  2. {{PGCH. 0534
  3. {{IDLH. 78875. Propylene dichloride
  4. Manfred Rossberg, Wilhelm Lendle, Gerhard Pfleiderer, Adolf Tögel, Eberhard-Ludwig Dreher, Ernst Langer, Heinz Rassaerts, Peter Kleinschmidt, Heinz Strack, Richard Cook, Uwe Beck, Karl-August Lipper, Theodore R. Torkelson, Eckhard Löser, Klaus K. Beutel, Trevor Mann "Chlorinated Hydrocarbons" in Ullmann's Encyclopedia of Industrial Chemistry 2006, Wiley-VCH, Weinheim. {{doi. 10.1002/14356007.a06_233.pub2.
  5. "ToxFAQs for 1,2-Dichloropropane".
  6. [http://www.mhlw.go.jp/stf/houdou/2r9852000002x6at.html Report by the Japanese Ministry of Health, Labour and Welfare]
  7. [http://www.yomiuri.co.jp/national/news/20130314-OYT1T00708.htm Article] in the [[Yomiuri Shimbun]]
  8. [https://www.cdc.gov/niosh/npg/npgd0534.html CDC - NIOSH Pocket Guide to Chemical Hazards]
  9. [https://www.cdc.gov/niosh/idlh/78875.html Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)]
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

chloroalkanes sweet-smelling-chemicals iarc-group-1-carcinogens
Want to explore this topic further?

Ask Mako anything about 1,2-Dichloropropane — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report