science › medicine medicine Articles Supervised harvesting of expression trees We propose a new method for supervised learning from gene expression data. We call it 'tree harvesting'. This technique … The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates Uracil DNA glycosylases (UDGs) are major repair enzymes that protect DNA from mutational damage caused by uracil incorpo… Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture — primary culture cells markedly differ from fourth-passage cells culture. Heterogeneous nuclear ribonucleoproteins C1/C2 identified as autoantigens by biochemical and mass spectrometric methods The antigenic specificity of an unusual antinuclear antibody pattern in three patient sera was identified after separati… A direct method to visualise the aryl acylamidase activity on cholinesterases in polyacrylamide gels In vertebrates, two types of cholinesterases exist, acetylcholinesterase and butyrylcholinesterase. The function of acet… High frequency oscillatory ventilation attenuates the activation of alveolar macrophages and neutrophils in lung injury Recent investigations have shown that leukocyte activation is involved in the pathogenesis of ventilator-associated lung… Polymorphic repeat in AIB1 does not alter breast cancer risk repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population. ] … Genetic snapshots of the Rhizobium species NGR234 genome ) was analyzed by shotgun sequencing. . As non-overlapping shotgun sequences together represent approximately 10% of ANU… Survival of patients transferred to tertiary intensive care from rural community hospitals Accessibility to tertiary intensive care resources differs among hospitals within a rural region. Determining whether ac… Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans expressing dousble-stranded RNA corresponding to a specific gene. An optimized feeding method is presented that results … Brain dystrophin-glycoprotein complex: Persistent expression of beta-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy Aside from muscle, brain is also a major expression site for dystrophin, the protein whose abnormal expression is respon… Phylogenetic analysis of methanogens from the bovine rumen Interest in methanogens from ruminants has resulted from the role of methane in global warming and from the fact that ca… An investigation of soy intake and mammographic characteristics in Hawaii This cross-sectional investigation in Hawaii explored the relation between soy foods and mammographic characteristics us… Quantitation of Pseudomonas aeruginosa in wound biopsy samples: from bacterial culture to rapid `real-time' polymerase chain reaction colony-forming units (CFU)/g tissue or a few copies per reaction. The time from sample collection to result was less tha… Use of molecular beacons to verify that the serine hydroxymethyltransferase pseudogene SHMT-ps1 is unique to the order Primates were used in an attempt to verify this suggestion. is present in both Old World and New World species but not among pros… Biphasic positive airway pressure ventilation (PeV+) in children Biphasic positive airway pressure (BIPAP) (also known as PeV+) is a mode of ventilation with cycling variations between … Development of a 950-gene DNA array for examining gene expression patterns in mouse testis Over the past five years, interest in and use of DNA array technology has increased dramatically, and there has been a s… Weight loss maintenance in women two to eleven years after participating in a commercial program: a survey . Randomly picked subjects answered a telephone questionnaire. Participants, 291 adult women from various regions of the… Gene expression changes during murine postnatal brain development For most vertebrate organs and tissues, the majority of development occurs during embryogenesis, and postnatal changes a… High affinity binding of proteins HMG1 and HMG2 to semicatenated DNA loops . , and the half-life of the complex is longer than one hour in vitro. Of all DNA structures described so far with which… In silico discovery of novel Retinoic Acid Receptor agonist structures Several Retinoic Acid Receptors (RAR) agonists have therapeutic activity against a variety of cancer types; however, una… A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells Bruton's tyrosine kinase (Btk) is essential for B cell development and function. Mutations of Btk elicit X-linked agamma… Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the prese… Heliox improves pulmonary mechanics in a pediatric porcine model of
induced severe bronchospasm and independent lung mechanical ventilation A helium-oxygen gas mixture (heliox) has low gas density and low
turbulence and resistance through narrowed airways.… Helium-oxygen mixture does not improve gas exchange in mechanically ventilated children with bronchiolitis Varying concentrations of helium-oxygen (heliox) mixtures were evaluated in mechanically ventilated children with bronch… Apolipoprotein E gene polymorphism is not a strong risk factor for diabetic nephropathy and retinopathy in Type I diabetes: case-control study gene for the development of diabetic retinopathy and nephropathy. genotypes frequencies differed between Type I diabetic… A comparison of volume control and pressure-regulated volume control ventilation in acute respiratory failure O) and survival. < 0.0001). No other statistically significant differences were found. Peak inspiratory pressure was sig… Impact of nosocomial pneumonia on the outcome of mechanically-ventilated patients = 314) were prospectively evaluated, and the prognostic factors of NP, which have been identified in previous studies, w… Road trips and resources: there is a better way ) designed to provide both intensive care unit (ICU) support and transport capability. We hypothesized that the use of t… Survey of stress ulcer prophylaxis No surveys of stress ulcer prophylaxis prescribing in the USA have
been conducted since 1995. Since that time, the most … The use of cephalad cannulae to monitor jugular venous oxygen content during extracorporeal membrane oxygenation ) in this patient population. = 0.01). in neonates and children treated with ECMO. Low systemic vascular resistance: differential diagnosis and
outcome To determine the frequency and prognosis of the various causes of
low systemic vascular resistance (SVR). Analysis o… Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the prese… Heliox improves pulmonary mechanics in a pediatric porcine model of
induced severe bronchospasm and independent lung mechanical ventilation A helium-oxygen gas mixture (heliox) has low gas density and low
turbulence and resistance through narrowed airways.… Helium-oxygen mixture does not improve gas exchange in mechanically ventilated children with bronchiolitis Varying concentrations of helium-oxygen (heliox) mixtures were evaluated in mechanically ventilated children with bronch… The Million Women Study: design and characteristics of the study population To describe the design of the Million Women Study and the characteristics of the study population. Population-based coho… Evidence for symmetric chromosomal inversions around the replication origin in bacteria Whole-genome comparisons can provide great insight into many aspects of biology. Until recently, however, comparisons we… Genomic structure of the gene for mouse germ cell nuclear factor (GCNF) gene is expressed in the placenta and the developing nervous system and germ cells, and responds to retinoic acid. gene … Spontaneous rupture of malarial spleen: two case reports and review of literature Malaria has long been among the most common diseases in the southeast Anatolia region of Turkey. In 1992, 18676 cases we… Abdominal compartment syndrome: does intra-cystic pressure reflect actual intra-abdominal pressure? A prospective study in surgical patients Abdominal compartment syndrome is defined as the adverse physiologic effects of increased intra-abdominal pressure. Prol… Heat stress is associated with decreased lactic acidemia in rat sepsis Elevated plasma lactate has been shown to correlate with mortality in patients with septic shock. Heat stress prior to s… Protection against cartilage and bone destruction by systemic
interleukin-4 treatment in established murine type II collagen-induced
arthritis Destruction of cartilage and bone are hallmarks of human rheumatoid
arthritis (RA), and controlling these erosive pr… The effects of 1α,25-dihydroxyvitamin D3 on matrix metalloproteinase and prostaglandin E2 production by cells of the rheumatoid lesion . ) production in two cell types known to express chondrolytic enzymes. production. by enzyme-linked immunosorbent assay… DNA loops and semicatenated DNA junctions Alternative DNA conformations are of particular interest as potential signals to mark important sites on the genome. The… Acute-phase serum amyloid A production by rheumatoid arthritis
synovial tissue The known
association between the acute-phase response and progressive joint damage may
be the direct result of … A new prototype of an electronic jet-ventilator and its humidification
system Adequate humidification in long-term jet ventilation is a critical
aspect in terms of clinical safety. To assess a p… Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study The aim of this prospective study was to assess whether the presence of septic shock could influence the dose response t… Estrogen receptor of primary breast cancers: evidence for intracellular proteolysis Iodinated oestradiol-labeled oestrogen receptor (ER) isoforms devoid of amino-terminal ABC domains represent about two-t… Expression profiles during honeybee caste determination Depending on their larval environment, female honeybees develop into either queens or workers. As in other polyphenisms,… FcgammaR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA) C57BL/6 mice, which lack functional FcγRI and RIII, inflammation and cartilage destruction were prevented. When ICA was …