RBMX

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title: "RBMX" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in humans" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/RBMX" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in humans ::

Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the RBMX gene.

Function

This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified but their biological nature has not been determined.

Interactions

RBMX has been shown to interact with SFRS10 and CDC5L.

References

References

1. (Jul 1999). "The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome". Nature Genetics.
2. (Jul 1999). "RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene". Nature Genetics.
3. "Entrez Gene: RBMX RNA binding motif protein, X-linked".
4. (Aug 2002). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Human Molecular Genetics.
5. (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal.

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