CDC5L
Protein-coding gene in humans
title: "CDC5L" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in humans" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/CDC5L" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Protein-coding gene in humans ::
Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.
Function
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.
Interactions
CDC5L has been shown to interact with:
- ASF/SF2,
- BZW1,
- CWC15,
- DNA-PKcs,
- DYNC1H1,
- GCN1L1,
- HSPA8,
- ILF2,
- PLRG1,
- PPM1D,
- PPP1CA,
- PRPF19,
- RBMX and
- RPL12,
- RPL13,
- RPS16,
- RPS25,
- SF3A1,
- SF3B1,
- SF3B2,
- SF3B4,
- SFPQ,
- SRSF2,
- SNRPA1,
- SNRPD3,
- SRRM1,
- Small nuclear ribonucleoprotein D1,
- Small nuclear ribonucleoprotein D2,
- Small nuclear ribonucleoprotein polypeptide A,
- TOP2A, and
- TTF2.
References
References
- (Apr 1998). "Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia". Genomics.
- (Feb 1997). "Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling". The Journal of Biological Chemistry.
- "Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)".
- (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology.
- (Nov 2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Research.
- (Nov 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". The Journal of Biological Chemistry.
- (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal.
- (Sep 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications.
::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::