Pridefine

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Chemical compound

title: "Pridefine" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["antidepressants", "pyrrolidines", "serotonin–norepinephrine–dopamine-reuptake-inhibitors", "serotonin-norepinephrine-dopamine-releasing-agents"] description: "Chemical compound" topic_path: "general/antidepressants" source: "https://en.wikipedia.org/wiki/Pridefine" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| IUPAC_name = 3-(Diphenylmethylidene)-1-ethylpyrrolidine | image = Pridefine Structure.svg | image_class = skin-invert-image

| tradename = | pregnancy_category = | legal_status = Uncontrolled | routes_of_administration = Oral

| bioavailability = | metabolism = | elimination_half-life = | excretion =

| C=19 | H=21 | N=1

Pridefine (AHR-1,118) is a drug which was investigated as an antidepressant in the late 1970s and early 1980s, but was never marketed. It acts as a balanced reuptake inhibitor of serotonin, dopamine, and norepinephrine, and also has some weak releasing activity.

In clinical trials pridefine was found to be as efficacious as the tricyclic antidepressants amitriptyline and imipramine in the treatment of major depressive disorder but was much more tolerable in comparison and also had an earlier onset of action. It has been shown to be effective in the treatment of alcoholism as well.

(1980). "Action of the antidepressant pridefine (AHR-1118) on biogenic amines in the rat brain". [[Biochemical Pharmacology (journal).
(1980). "Open trial evaluation of a pyrrolidine derivative (AHR-1118) on norepinephrine metabolism". [[Progress in Neuro-Psychopharmacology]].
(1981). "Noncompetitive amine uptake inhibition by the new antidepressant pridefine". [[Journal of Neurochemistry]].

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