Mogroside

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title: "Mogroside" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["triterpene-glycosides", "sugar-substitutes"] description: "Group of chemical compounds" topic_path: "general/triterpene-glycosides" source: "https://en.wikipedia.org/wiki/Mogroside" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Group of chemical compounds ::

::figure[src="https://upload.wikimedia.org/wikipedia/commons/6/6e/Mogroside_II_E.svg" caption="Structural formula of [[mogroside 2 E"] ::

A mogroside is a triterpene glycoside of cucurbitane derivatives found in certain plants, such as the fruit of the gourd vine Siraitia grosvenorii (known as monkfruit or luohan guo). Mogrosides are extracted from S. grosvenorii and used in the manufacture of sugar substitutes.

Mogrosides

::figure[src="https://upload.wikimedia.org/wikipedia/commons/7/73/Mogrosid_V.svg" caption="Structural formula of [[mogroside V"] ::

::figure[src="https://upload.wikimedia.org/wikipedia/commons/e/e9/Mogroside_VI.svg" caption="Structural formula of [[mogroside VI"] ::

Mogrosides include:

• Mogrol
• Mogroside II A1
• Mogroside II B
• 7-Oxomogroside II E
• 11-Oxomogroside A1
• Mogroside III A2
• 11-Deoxymogroside III
• 11-Oxomogroside IV A
• Mogroside V
• 7-Oxomogroside V
• 11-Oxo-mogroside V
• Mogroside VI
• Siamenoside I

The total content of mogrosides in Siraitia grosvenorii fruit is 3.8% with Mogroside V having the highest content (0.8% to 1.3% w/w).

Biosynthesis

One analysis of 200 candidate genes of Siraitia grosvenorii revealed five enzyme families involved in the synthesis of mogroside V: squalene epoxidases, triterpenoid synthases, epoxide hydrolases, cytochrome P450s, and UDP-glucosyltransferases. The metabolic pathway for mogroside biosynthesis involves an initial stage of fruit development when squalene is metabolized to di-glucosylated, tetra-hydroxycucurbitadienols, then during fruit maturation, branched glucosyl groups are added and catalyzed, leading to the sweet M4, M5, and M6 mogrosides.

Stability

Mogroside V appears to be heat stable in the range of 100 to 150 degrees Celsius for 4 hours and up to 8 hours in boiling water. It is stable at a pH of between 3 and 12 when stored from 2 to 8 degrees Celsius.

Uses

Some mogrosides are used in traditional Chinese medicine and some are extracted for manufacturing as sweeteners. Mogroside V extract from S. grosvenorii fruit is 250 times sweeter than sucrose, sold commercially in Norbu (sweetener).

References

References

1. (2016). "The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii". Proceedings of the National Academy of Sciences of the United States of America.
2. Subhuti Dharmananda (January 2004), [http://www.itmonline.org/arts/luohanguo.htm "Luo han guo - Sweet fruit used as sugar substitute and medicinal herb"]. Institute for Traditional Medicine, Portland, Oregon.
3. (2024). "A comprehensive review of Siraitia grosvenorii (Swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications". [[Frontiers Media#List of journals.
4. (11 December 2019). "Safety of use of Monk fruit extract as a food additive in different food categories". EFSA Journal.

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