MiR-150

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Family of microRNA precursors found in mammals

title: "MiR-150" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["microrna"] description: "Family of microRNA precursors found in mammals" topic_path: "general/microrna" source: "https://en.wikipedia.org/wiki/MiR-150" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Family of microRNA precursors found in mammals ::

::data[format=table title="Infobox rfam"]

FieldValue
NamemiR-150
imageMir-150 SS.png
captionConserved secondary structure of miR-150 microRNA precursor
SymbolmiR-150
AltSymbolsMIR150
RfamRF00767
miRBaseMI0000479
miRBase_familyMIPF0000197
RNA_typemiRNA
Tax_domainMammalia
GO0035195
SO0001244
EntrezGene406942
HGNCid31537
OMIM610566
RefSeqNR_029703
Chromosome19
Armq
Band13.33
::

| Name = miR-150 | image =Mir-150 SS.png | width = | caption = Conserved secondary structure of miR-150 microRNA precursor | Symbol = miR-150 | AltSymbols = MIR150 | Rfam = RF00767 | miRBase = MI0000479 | miRBase_family = MIPF0000197 | RNA_type = miRNA | Tax_domain = Mammalia | GO = 0035195 | SO = 0001244 | CAS_number = | EntrezGene = 406942 | HGNCid = 31537 | OMIM = 610566 | PDB = | RefSeq = NR_029703 | Chromosome = 19 | Arm = q | Band = 13.33 | LocusSupplementaryData = miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.

miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes. It is also thought to control B and T cell differentiation, alongside miR-155.

Role in cancer

miR-150 has been linked with a number of cancers. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than 50x overexpressed in osteosarcoma.

Applications

miR-150 levels in blood plasma can be indicative of early sepsis; it could have a future use therapeutically in treating the condition. In addition, miR-150 is one of a number of microRNAs whose expression profile could be used as a biomarker of hepatocellular carcinoma.

References

References

  1. (Dec 2001). "microRNAs: tiny regulators with great potential". Cell.
  2. (Nov 2005). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell.
  3. (Jun 2008). "MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors". Developmental Cell.
  4. (May 2011). "MicroRNAs in platelet production and activation". Blood.
  5. (Jan 2010). "The role of microRNAs in normal and malignant hematopoiesis". European Journal of Haematology.
  6. (Jul 2008). "MicroRNAs in normal and malignant hematopoiesis". Current Opinion in Hematology.
  7. (2011). "Identification of Differentially Expressed MicroRNAs in Osteosarcoma". Sarcoma.
  8. (2009-10-12). "MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis". PLOS ONE.
  9. (Aug 2009). "Altered microRNA Expression Patterns in Hepatoblastoma Patients". Translational Oncology.

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microrna