MiR-208
title: "MiR-208" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["microrna", "biomarkers"] topic_path: "general/microrna" source: "https://en.wikipedia.org/wiki/MiR-208" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::data[format=table title="Infobox rfam"]
| Field | Value |
|---|---|
| Name | miR-208 |
| image | Mir-208 SS.png |
| caption | Conserved secondary structure of miR-208 microRNA precursor |
| Symbol | miR-208 |
| AltSymbols | MIR208 |
| Rfam | RF00749 |
| miRBase | MI0000251 |
| miRBase_family | MIPF0000178 |
| RNA_type | miRNA |
| Tax_domain | Metazoa |
| GO | 0035195 |
| SO | 0001244 |
| EntrezGene | 406990 |
| HGNCid | 31585 |
| OMIM | 611116 |
| RefSeq | NR_029595 |
| Chromosome | 14 |
| Arm | q |
| Band | 11.2 |
| :: |
| Name = miR-208 | image = Mir-208 SS.png | width = | caption = Conserved secondary structure of miR-208 microRNA precursor | Symbol = miR-208 | AltSymbols = MIR208 | Rfam = RF00749 | miRBase = MI0000251 | miRBase_family = MIPF0000178 | RNA_type = miRNA | Tax_domain = Metazoa | GO = 0035195 | SO = 0001244 | CAS_number = | EntrezGene = 406990 | HGNCid = 31585 | OMIM = 611116 | PDB = | RefSeq = NR_029595 | Chromosome = 14 | Arm = q | Band = 11.2 | LocusSupplementaryData = miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.
In humans, the gene for miR-208 is located in an intron of MYH7.
Function
miR-208 has been deemed a "myomiR" as it is specifically expressed, or found at much higher levels, in cardiac tissue. Other myomiRs include miR-1 and miR-133. miR-208 is thought to be dysregulated in various cardiovascular diseases.
miR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development. It also responds to stress and forms part of a hormonal signalling cascade in cardiac cells.
Applications
A preliminary study has shown a potential use in the prognosis of dilated cardiomyopathy. Another application has been suggested as using plasma concentration of miR-208 as a biomarker of damaged cardiac muscle cells.
References
References
- (December 2001). "microRNAs: tiny regulators with great potential". Cell.
- (November 2005). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell.
- (Mar–Apr 2011). "MicroRNAs in cardiomyocyte development". Wiley Interdisciplinary Reviews: Systems Biology and Medicine.
- (2010). "The roles of microRNAs in heart diseases: a novel important regulator". Current Medicinal Chemistry.
- (May 2011). "MicroRNAs in the cardiovascular system". Current Opinion in Cardiology.
- (April 2007). "Control of stress-dependent cardiac growth and gene expression by a microRNA". Science.
- (May 2010). "Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy". Journal of Cardiac Failure.
- (November 2009). "Plasma miR-208 as a biomarker of myocardial injury". Clinical Chemistry.
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