MDAT
Chemical compound
title: "MDAT" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["2-aminotetralins", "david-e.-nichols", "designer-drugs", "entactogens", "methylenedioxyphenethylamines", "serotonin-releasing-agents"] description: "Chemical compound" topic_path: "general/2-aminotetralins" source: "https://en.wikipedia.org/wiki/MDAT" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Chemical compound ::
::data[format=table title="Infobox drug"]
| Field | Value |
|---|---|
| image | 6,7-Methylenedioxy-2-aminotetralin.svg |
| image_class | skin-invert-image |
| width | 250px |
| class | Serotonin releasing agent; Entactogen |
| ATC_prefix | None |
| legal_status | Uncontrolled |
| index2_label | hydrochloride |
| CAS_number_Ref | |
| CAS_number | 101625-35-8 |
| CAS_number2_Ref | |
| CAS_number2 | 3446-21-8 |
| UNII_Ref | |
| UNII | 28IR5LC41Q |
| UNII2_Ref | |
| UNII2 | BOX4U52EET |
| PubChem | 36483 |
| ChemSpiderID | 33531 |
| synonyms | 6,7-MDAT; 6,7-Methylenedioxy-2-aminotetralin |
| IUPAC_name | 5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxol-6-amine |
| C | 11 |
| SMILES | C3Cc1cc2OCOc2cc1CC3N |
| :: |
| image = 6,7-Methylenedioxy-2-aminotetralin.svg | image_class = skin-invert-image | width = 250px
| tradename = | routes_of_administration = | class = Serotonin releasing agent; Entactogen | ATC_prefix = None
| legal_status = Uncontrolled
| index2_label = hydrochloride | CAS_number_Ref = | CAS_number = 101625-35-8 | CAS_number2_Ref = | CAS_number2 = 3446-21-8 | UNII_Ref = | UNII = 28IR5LC41Q | UNII2_Ref = | UNII2 = BOX4U52EET | PubChem = 36483 | ChemSpiderID = 33531 | synonyms = 6,7-MDAT; 6,7-Methylenedioxy-2-aminotetralin
| IUPAC_name = 5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxol-6-amine | C=11 | H=13 | N=1 | O=2 | SMILES = C3Cc1cc2OCOc2cc1CC3N
MDAT, also known as 6,7-methylenedioxy-2-aminotetralin, is a drug of the 2-aminotetralin family developed in the 1990s by a team at Purdue University led by David E. Nichols. It appears to act as a serotonin releasing agent based on rodent drug discrimination assays comparing it to MDMA, in which it fully substitutes for, and additionally lacks any kind of serotonergic neurotoxicity. Hence, MDAT is considered likely to be a non-neurotoxic, putative entactogen in humans.
References
References
- (February 1990). "Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA)". Journal of Medicinal Chemistry.
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