JWH-210

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Chemical compound

title: "JWH-210" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["jwh-cannabinoids", "naphthoylindoles", "designer-drugs", "cb1-receptor-agonists", "cb2-receptor-agonists"] description: "Chemical compound" topic_path: "general/jwh-cannabinoids" source: "https://en.wikipedia.org/wiki/JWH-210" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| Verifiedfields = changed | verifiedrevid = 451554694 | IUPAC_name = 4-Ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone | image = JWH-210.svg | image_class = skin-invert-image | width = 180

| tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_BR = F2 | legal_BR_comment = | legal_CA = Schedule II | legal_UK = Class B | legal_US = Schedule I | legal_DE = Anlage II | legal_status = Illegal in Sweden, I-N (Poland) | routes_of_administration =

| bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion =

| CAS_number_Ref = | CAS_number = 824959-81-1 | CAS_supplemental = (JWH-210) (JWH-182) | UNII_Ref = | UNII = R18JYO04PY | ATC_prefix = | ATC_suffix = | PubChem = 45270396 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 24617616

| C=26 | H=27 | N=1 | O=1 | smiles = c4cccc2c4c(CC)ccc2C(=O)c(c3)c1ccccc1n3CCCCC | StdInChI_Ref = | StdInChI = 1S/C26H27NO/c1-3-5-10-17-27-18-24(22-13-8-9-14-25(22)27)26(28)23-16-15-19(4-2)20-11-6-7-12-21(20)23/h6-9,11-16,18H,3-5,10,17H2,1-2H3 | StdInChIKey_Ref = | StdInChIKey = LACIUQLUNACUKC-UHFFFAOYSA-N

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB1 Ki 0.69 nM) and JWH-182 (CB1 Ki 0.65 nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2 nM). It was discovered by and named after John W. Huffman.

JWH-210 may be neurotoxic to animals when administered in high doses.

Legal status

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-210 are Schedule I Controlled Substances.

JWH-210 and JWH-122 were banned in Sweden on 1 October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" synthetic cannabis products. The substances JWH-210, JWH-122 and JWH-203 were classified as illegal drugs by the Swedish government as of 1 September 2011.

As of October 2015 JWH-210 is a controlled substance in China.

References

References

  1. Anvisa. (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
  2. "Stoffe gem. Anlagen zum BtMG".
  3. "Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii ( Dz.U. 2011 nr 105 poz. 614 )". Internetowy System Aktów Prawnych.
  4. (January 2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists". Bioorganic & Medicinal Chemistry.
  5. (November 2015). "Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210". Biomolecules & Therapeutics.
  6. {{UnitedStatesCode2. 21. 812. Schedules of controlled substances
  7. [http://www.riksdagen.se/webbnav/index.aspx?nid=3911&bet=1999:58 Swedish Code of Statutes Regulation (2010:1086).]
  8. "Swedish Code of Statutes Regulation (2010:1086). (pdf)".
  9. LVFS 2011:8
  10. (27 September 2015). "关于印发《非药用类麻醉药品和精神药品列管办法》的通知". China Food and Drug Administration.

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jwh-cannabinoidsnaphthoylindolesdesigner-drugscb1-receptor-agonistscb2-receptor-agonists