JWH-122

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Chemical compound

title: "JWH-122" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["jwh-cannabinoids", "naphthoylindoles", "designer-drugs", "cb1-receptor-agonists", "cb2-receptor-agonists"] description: "Chemical compound" topic_path: "general/jwh-cannabinoids" source: "https://en.wikipedia.org/wiki/JWH-122" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 459449749 | IUPAC_name = (4-Methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone | image = JWH-122.svg | image_class = skin-invert-image | CAS_number_Ref = | CAS_number = 619294-47-2 | UNII_Ref = | UNII = 44147RI31X | KEGG_Ref = | KEGG = C22796 | ATC_prefix = | ATC_suffix = | ChEMBL_Ref = | ChEMBL = 557004 | PubChem = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 24623066 | C = 25 | H = 25 | N = 1 | O = 1 | smiles = CCCCCn1cc(c2c1cccc2)C(=O)c3ccc(c4c3cccc4)C | StdInChI_Ref = | StdInChI = 1S/C25H25NO/c1-3-4-9-16-26-17-23(21-12-7-8-13-24(21)26)25(27)22-15-14-18(2)19-10-5-6-11-20(19)22/h5-8,10-15,17H,3-4,9,16H2,1-2H3 | StdInChIKey_Ref = | StdInChIKey = HUKJQMKQFWYIHS-UHFFFAOYSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU =
| pregnancy_US =
| pregnancy_category= | legal_AU = S9 | legal_BR = F2 | legal_BR_comment = | legal_CA = Schedule II | legal_UK = Class B | legal_US = Schedule I | legal_DE = Anlage II | routes_of_administration =

JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is a methylated analogue of JWH-018. It has a Ki of 0.69 nM at CB1 and 1.2 nM at CB2.

In January 2015, over 40 people were reportedly sickened after eating a holiday bread called Rosca de reyes purchased at a bakery in Santa Ana, California, that was laced with JWH-122.

pharmacology

compared with thc and its much more reduced binding affinity of just 40.4nM and therefore its ability to even reduce signalling then bodyown endocannabinoids, jwh 177 and other full agonists especially those with very potent binding affinitys of the 35-fold strongness of thc, synthetic cannabinoids can activade the endocanabinoid-system of the human body excessively.

Legal status

Australia

JWH-122 is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015). A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.

China

As of October 2015 JWH-122 is a controlled substance in China.

United States

In the United States, JWH-122 is a Schedule I Controlled Substance.

References

References

  1. Anvisa. (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial". [[Diário Oficial da União]].
  2. (2015-02-02). "Tests Show Synthetic Drug Contaminated Holiday Bread from CA Bakery". Food Safety News.
  3. (October 2015). "Poisons Standard". The Australian Government.
  4. (27 September 2015). "关于印发《非药用类麻醉药品和精神药品列管办法》的通知". China Food and Drug Administration.
  5. "Controlled Substances". U.S. Department of Justice, Drug Enforcement Division (DEA).

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jwh-cannabinoidsnaphthoylindolesdesigner-drugscb1-receptor-agonistscb2-receptor-agonists