James Rothman

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American biologist and Nobel laureate

title: "James Rothman" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["1950-births", "living-people", "nobel-laureates-in-physiology-or-medicine", "american-nobel-laureates", "richard-lounsbery-award-laureates", "21st-century-american-biologists", "columbia-university-faculty", "harvard-university-alumni", "members-of-the-european-molecular-biology-organization", "members-of-the-national-academy-of-medicine", "members-of-the-united-states-national-academy-of-sciences", "foreign-members-of-the-royal-society", "jewish-american-scientists", "princeton-university-faculty", "recipients-of-the-albert-lasker-award-for-basic-medical-research", "stanford-university-school-of-medicine-faculty", "yale-school-of-medicine-faculty", "yale-sterling-professors", "winners-of-the-heineken-prize", "pomfret-school-alumni", "kavli-prize-laureates-in-neuroscience", "american-fellows-of-the-royal-society"] description: "American biologist and Nobel laureate" topic_path: "science/biology" source: "https://en.wikipedia.org/wiki/James_Rothman" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary American biologist and Nobel laureate ::

::data[format=table title="Infobox scientist"]

FieldValue
nameJames Rothman
imageJames Edward Rothman.jpg
captionRothman in 2013
birth_nameJames Edward Rothman
birth_date
birth_placeHaverhill, Massachusetts, U.S.
fieldsCell biology
workplaces{{Plain list
* Stanford University<ref name"bio"
thesis_titleTransbilayer asymmetry and its maintenance in biological membranes
thesis_urlhttp://www.worldcat.org/oclc/76995813
thesis_year1976
alma_mater{{Plainlist
academic_advisorsHarvey Lodish
awards{{Plainlist
signature
website
::

| name = James Rothman | image = James Edward Rothman.jpg | image_size = | alt = | caption = Rothman in 2013 | birth_name = James Edward Rothman | birth_date = | birth_place = Haverhill, Massachusetts, U.S. | residence = | fields = Cell biology | workplaces = {{Plain list|

James Edward Rothman (born November 3, 1950) is an American biochemist. He is the Fergus F. Wallace Professor of Biomedical Sciences at Yale University, the Chairman of the Department of Cell Biology at Yale School of Medicine, and the Director of the Nanobiology Institute at the Yale West Campus. Rothman also concurrently serves as adjunct professor of physiology and cellular biophysics at Columbia University and a research professor at the UCL Queen Square Institute of Neurology, University College London.

Rothman was awarded the 2013 Nobel Prize in Physiology or Medicine, for his work on vesicle trafficking (shared with Randy Schekman and Thomas C. Südhof). He received many other honors including the King Faisal International Prize in 1996, the Louisa Gross Horwitz Prize from Columbia University and the Albert Lasker Award for Basic Medical Research both in 2002.

Education

Rothman earned his high school diploma from Pomfret School in 1967, then received his B.A. in physics at Yale University in 1971 and his Ph.D. in biological chemistry at Harvard in 1976 working with Eugene Patrick Kennedy.

Career and research

Following his Ph.D., Rothman did postdoctoral research with Harvey Lodish at Massachusetts Institute of Technology working on glycosylation of membrane proteins. He moved to the Department of Biochemistry at Stanford University in 1978. He was at Princeton University, from 1988 to 1991, before coming to New York to found the Department of Cellular Biochemistry and Biophysics at Memorial Sloan-Kettering Cancer Center, where he also served as vice-chairman of Sloan-Kettering Institute. In 2003, he left Sloan-Kettering to become a professor of physiology at Columbia University's College of Physicians and Surgeons and the head of Columbia's Center for Chemical Biology. He moved from Columbia to Yale in 2008, retaining a part-time appointment at Columbia. Since 2013 he is also holding a position as Distinguished Professor-in-Residence at the Shanghai Institute for Advanced Immunochemical Studies of ShanghaiTech University.

In 1995, Rothman joined the Amersham plc scientific advisory board. When Amersham was acquired by GE Healthcare in 2003, Rothman was appointed as the Chief Science Advisor to GE Healthcare.

::figure[src="https://upload.wikimedia.org/wikipedia/commons/8/86/Nobel_prize_for_J.Rothman._Sthlm2013.JPG" caption="Nobel Prize Ceremony: James Rothman receives his award from king of Sweden."] ::

Rothman's research details how vesicles—tiny sac-like structures that transport hormones, growth factors, and other molecules within cells—know how to reach their correct destination and where and when to release their contents. This cellular trafficking underlies many critical physiological functions, including the propagation of the cell itself in division, communication between nerve cells in the brain, secretion of insulin and other hormones in the body, and nutrient uptake. Defects in this process lead to a wide variety of conditions, including diabetes and botulism.

His former postdoctoral students include Gero Miesenböck (postdoc){{Cite journal | doi = 10.1073/pnas.94.7.3402 | last1 = Miesenböck | first1 = G. | last2 = Rothman | first2 = J. E. | title = Patterns of synaptic activity in neural networks recorded by light emission from synaptolucins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 7 | pages = 3402–3407 | year = 1997 | pmid = 9096406 | pmc = 20382 | bibcode = 1997PNAS...94.3402M | doi-access = free }}{{Cite journal | last1 = Miesenböck | first1 = G. | last2 = De Angelis | first2 = D. A. | last3 = Rothman | first3 = J. E. | doi = 10.1038/28190 | title = Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins | journal = Nature | volume = 394 | issue = 6689 | pages = 192–195 | year = 1998 | pmid = 9671304 | bibcode = 1998Natur.394..192M | s2cid = 4320849

Awards and honors

Rothman was awarded the 2010 Kavli Prize Neuroscience together with Richard Scheller and Thomas C. Südhof for "discovering the molecular basis of neurotransmitters release".

Rothman was awarded the 2013 Nobel Prize in Physiology or Medicine together with Randy Schekman and Thomas C. Südhof for "their discoveries of machinery regulating vesicle traffic, a major transport system in our cells."

Rothman is a Member of the National Academy of Sciences and its Institute of Medicine.

Personal life

He is the son of Martin Rothman, a pediatrician, and Gloria Hartnick, both Jewish.

References

References

  1. "James E. Rothman, Faculty: Yale Department of Chemistry". Chem.yale.edu.
  2. "James E Rothman".
  3. "P&S Adjunct Faculty Member Wins 2013 Nobel Prize". Columbia Newsroom.
  4. (29 January 2018). "James E Rothman".
  5. {{Nobelprize
  6. "The Nobel Prize in Physiology or Medicine 2013". Nobel Foundation.
  7. "KFIP Winners Archive". King Faisal Foundation.
  8. (2015). "A conversation with James Rothman". Journal of Clinical Investigation.
  9. (2013). "Profile of Thomas Sudhof, James Rothman, and Randy Schekman, 2013 Nobel Laureates in Physiology or Medicine". Proceedings of the National Academy of Sciences.
  10. (October 7, 2013). "Yale's James Rothman shares 2013 Nobel Prize in Physiology or Medicine". Yale News.
  11. "Leading Cell Biologist Joins Columbia University College of Physicians & Surgeons". Columbia Medical Center Newsroom.
  12. "ShanghaiTech professor named 'Highly Cited Researcher'".
  13. (October 10, 2003). "GE Acquires Amersham for $9.5 Billion; 800p Per Share Offer in All Stock Transaction".
  14. (November 8, 2011). "James Rothman Named Chief Scientific Advisor at VR Laboratories".
  15. {{Scopus
  16. {{cite q. Q39664981
  17. (September 6, 2010). "JAMES ROTHMAN". Kavlifoundation.org.
  18. Altman, Lawrence. (October 7, 2013). "3 Win Joint Nobel Prize in Medicine". NY Times.
  19. (October 7, 2013). "James E. Rothman, PhD '76, Shares Nobel Prize for Medicine". Harvard Magazine.
  20. "The Nobel Prize in Physiology or Medicine 2013". Nobel Prize.
  21. AP and ToI Staff. (October 7, 2013). "Israelis lose out to US-German trio for Nobel medicine prize".

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