Chromone

Quality 0.50 · 0 views · Updated 2 months ago

title: "Chromone" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["chromones"] topic_path: "general/chromones" source: "https://en.wikipedia.org/wiki/Chromone" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 399524554 | ImageFile= chromone.svg | ImageSize= 150px | IUPACName= Chromen-4-one | PIN = 4H-1-Benzopyran-4-one | OtherNames=4-Chromone; 1,4-Benzopyrone; 4H-Chromen-4-one; Benzo-gamma-pyrone; 1-Benzopyran-4-one; 4H-Benzo(b)pyran-4-one |Section1={{Chembox Identifiers | CASNo_Ref = | CASNo=491-38-3 | UNII_Ref = | UNII = 20C556MJ76 | PubChem=10286 | ChEBI_Ref = | ChEBI = 72013 | ChEMBL_Ref = | ChEMBL = 13311 | SMILES = O=C1C=COc2ccccc12 | ChemSpiderID_Ref = | ChemSpiderID = 9866 | InChI = 1/C9H6O2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H | InChIKey = OTAFHZMPRISVEM-UHFFFAOYAY | StdInChI_Ref = | StdInChI = 1S/C9H6O2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H | StdInChIKey_Ref = | StdInChIKey = OTAFHZMPRISVEM-UHFFFAOYSA-N |Section2={{Chembox Properties | C=9 | H=6 | O=2 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= | pKa=−2.0 (of conjugate acid) |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt =

Chromone (or 1,4-benzopyrone) is a derivative of benzopyran with a substituted keto group on the pyran ring. It is an isomer of coumarin.

Derivatives of chromone are collectively known as chromones. Most, though not all, chromones are also phenylpropanoids.

Examples

6,7-dimethoxy-2,3-dihydrochromone has been isolated from Sarcolobus globosus.
Altechromone A can be isolated from fungi such as Alternaria sp.
Eucryphin, a chromone rhamnoside, can be isolated from the bark of Eucryphia cordifolia.
Cromolyn (disodium cromoglicate) was found to inhibit antigen challenge as well as stress induced symptoms. Cromoglicate is used as a mast cell stabilizer in allergic rhinitis, asthma and allergic conjunctivitis.
Nedocromil sodium was found to have a somewhat longer half-life than cromolyn; however, production was discontinued in the US in 2008.
Xanthone with a second aromatic ring.

References

Königs, P.. (2010-12-27). "Structural Revision and Synthesis of Altechromone A". Journal of Natural Products.
Eucryphin, a new chromone rhamnoside from the bark of Eucryphia cordifolia. R. Tschesche, S. Delhvi, S. Sepulveda and E. Breitmaier, Phytochemistry, Volume 18, Issue 5, 1979, pages 867–869, {{doi. 10.1016/0031-9422(79)80032-1
HOWELL, J.B. & ALTOUNYAN, R.E. (1967). A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma. Lancet, 2, 539–542. [https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?holding=npg&cmd=Retrieve&db=PubMed&list_uids=4166895&dopt=Abstract Abstract]

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::