CBX3

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title: "CBX3" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["transcription-factors"] description: "Protein-coding gene in humans" topic_path: "arts/film" source: "https://en.wikipedia.org/wiki/CBX3" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in humans ::

Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.

Interactions

CBX3 has been shown to interact with PIM1, Ki-67, Lamin B receptor, CBX5 and CBX1.

References

References

1. (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem.
2. "Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)".
3. Koike, N. (February 2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett..
4. Kametaka, Ai. (December 2002). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells.
5. Ye, Q. (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem..
6. Nielsen, A L. (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell.

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