Calgranulin
Protein
title: "Calgranulin" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["s100-proteins"] description: "Protein" topic_path: "general/s100-proteins" source: "https://en.wikipedia.org/wiki/Calgranulin" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Protein ::
::figure[src="https://upload.wikimedia.org/wikipedia/commons/6/66/1gqm.jpg" caption="Calgranulin C hexamer, Human."] ::
**Calgranulin ** is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils.
The proteins S100A8 and S100A9 form a heterodimer called calprotectin.
Human genes
Function
Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations. Thus, it may also function in vivo as an inhibitor of calcium oxalate kidney stone formation. However, the role of calgranulin in the stone formation process has not been evaluated.
References
References
- (1 August 1998). "Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization". Am J Physiol.
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