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Serotonin–norepinephrine releasing agent

Drug class

A serotonin–norepinephrine releasing agent (SNRA) is a type of drug which induces the release of serotonin and norepinephrine (and epinephrine) in the body and/or brain.

Only a few SNRAs are known, examples of which include norfenfluramine, (R)-MDMA, MBDB, and MDAI. Fenfluramine produces norfenfluramine as a major active metabolite and hence is an SNRA similarly. It was formerly used as an appetite suppressant for the treatment of obesity. (R)-MDMA, MBDB, and MDAI are entactogens. Dexfenfluramine is also an SNRA.

A closely related type of drug is a serotonin–norepinephrine reuptake inhibitor (SNRI).

Mechanism of action

Main article: Monoamine releasing agent#Mechanism of action

References

Dyballa, Sylvia. (2019-10-01). "Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans". Toxicological Sciences.

Info: Wikipedia Source

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