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Γ-Lactone

Γ-Lactone

γ-Lactones are a family of organic compounds with the formula cyclo-. The parent member is γ-butyrolactone (R = H). A commercially important set of γ-lactones are derived from the free radical addition of fatty alcohols and acrylic acid. They are all weakly volatile liquids, which are colorless when pure, but typical samples are not.

NameFormulaRegistry numberNotes
γ-Octalactone104-50-7fruity
γ-Nonalactone104-61-0coconut-like
γ-Decalactone706-14-9peach flavors
γ-Undecalactone104-67-6peach flavors
β-Methyl-γ-octalactone39212-23-2whisky lactone

Production

Chemical, biological, and hybrid routes have been developed for these fragrances. Some fungal enzymes hydroxylate fatty acids, leading to the corresponding lactones. In terms of chemical routes, fatty alcohols undergo free radical addition to acrylic acid, giving hydroxy carboxylic acids, which spontaneously lactonize.

chemical route to gamma-lactones from fatty alcohols

References

References

  1. (2016). "Ullmann's Encyclopedia of Industrial Chemistry".
  2. (2011). "Biochemistry of lactone formation in yeast and fungi and its utilisation for the production of flavour and fragrance compounds". Applied Microbiology and Biotechnology.
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