Dizziness

Mechanism and causes

Many conditions cause dizziness because multiple parts of the body are required for maintaining balance including the inner ear, eyes, muscles, skeleton, and the nervous system. Thus dizziness can be caused by a variety of problems and may reflect a focal process (such as one affecting balance or coordination) or a diffuse one (such as a toxic exposure or low perfusion state).

Common causes of dizziness include:

• Inadequate blood supply to the brain due to:
  • A sudden fall in blood pressure
  • Heart problems or artery blockages
  • Anemias, such as vitamin B12 deficiency anemia, iron deficiency anemia
• Loss or distortion of vision or visual cues
• Standing too quickly/prolonged standing
• Vertigo
• Disorders of the inner ear
• Dehydration
• Distortion of neurological function by medications such as anticonvulsants and sedatives
• Dysfunction of cervical proprioception
• Side effects from other prescription drugs, such as proton-pump inhibitors or coumadin (warfarin)

Diagnosis

Differential diagnosis

Dizziness may occur from an abnormality involving the brain (in particular the brainstem or cerebellum), inner ear, eyes, heart, vascular system, fluid or blood volume, spinal cord, peripheral nerves, or body electrolytes. Dizziness can accompany certain serious events, such as a concussion or brain bleed, epilepsy and seizures (convulsions), stroke, and cases of meningitis and encephalitis. However, the most common subcategories can be broken down as follows: 40% peripheral vestibular dysfunction, 10% central nervous system lesion, 15% psychiatric disorder, 25% presyncope/disequilibrium, and 10% nonspecific dizziness. Some vestibular pathologies have symptoms that are comorbid with mental disorders.

While traditional medical teaching has focused on determining the cause of dizziness based on the category (such as vertigo vs. presyncope), research published in 2017 suggests that this analysis is of limited clinical utility.

Medical conditions that often have dizziness as a symptom include:

• Benign paroxysmal positional vertigo
• Ménière's disease
• Labyrinthitis
• Otitis media
• Brain tumor
• Acoustic neuroma
• Motion sickness
• Ramsay Hunt syndrome
• Fatal Familial Insomnia
• Migraine
• Multiple sclerosis
• Pregnancy
• Low blood pressure (hypotension)
• Low blood oxygen content (hypoxemia)
• Heart attack
• Iron deficiency (anemia)
• Vitamin B12 deficiency
• Low blood sugar (hypoglycemia)
• Hormonal changes (e.g. thyroid disease, menstruation, pregnancy)
• Panic disorder
• Hyperventilation
• Anxiety
• Depression
• Age-diminished visual, balance, and perception of spatial orientation abilities
• Stroke; cause of isolated dizziness in 0.7% of people who present to the emergency department
• Post-concussion syndrome

Disequilibrium

In medicine, disequilibrium refers to impaired equilibrioception that can be characterised as a sensation of impending fall or of the need to obtain external assistance for proper locomotion. It is sometimes described as a feeling of improper tilt of the floor, or as a sense of floating. This sensation can originate in the inner ear or other motion sensors, or in the central nervous system. Neurologic disorders tend to cause constant vertigo or disequilibrium and usually have other symptoms of neurologic dysfunction associated with the vertigo. Many medications used to treat seizures, depression, anxiety, and pain affect the vestibular system and the central nervous system which can cause the symptom of disequilibrium.

References

References

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