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Barley yellow dwarf virus 5'UTR

FieldValue
NameBarley yellow dwarf virus 5' UTR
imageBYDV SS.png
captionConserved secondary structure of BYDV 5' UTR.
SymbolBYDV 5'UTR
RfamRF01508
RNA_typecis-regulatory element
Tax_domainbarley yellow dwarf

Barley yellow dwarf virus 5' UTR is a non-coding RNA element containing structural elements required for translation of the genome of the plant disease pathogen Barley yellow dwarf virus.

Unlike eukaryotic mRNA, this virus lacks a 5' cap and a poly(A) tail but still circularises its mRNA through base pairing between two stem loops, one located in the 5' untranslated region (UTR) and the other within the 3' UTR. The structure within the 3' UTR has been previously characterised as the 3' cap-independent translation element (3' TE element) and the 5' UTR of barley yellow dwarf virus has been predicted to contain 4 stem loop structures. Mutagenesis showed that stem loop 4 is essential for base pairing with 3'TE and only 5 bases are needed to base pair for mRNA circularization to occur.

References

References

  1. (July 1997). "A viral sequence in the 3'-untranslated region mimics a 5' cap in facilitating translation of uncapped mRNA". The EMBO Journal.
  2. (May 2001). "Base-pairing between untranslated regions facilitates translation of uncapped, nonpolyadenylated viral RNA". Molecular Cell.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

non-coding-rna gene-expression
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