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Β-Hydroxythiofentanyl

Opioid analgesic drug

Field	Value
drug_name	β-Hydroxythiofentanyl
verifiedrevid	410873709
IUPAC_name	N-{1-[2-Hydroxy-2-(thiophen-2-yl)ethyl]piperidin-4-yl}-N-phenylpropanamide
image	Betahydroxythiofentanyl.svg
image_class	skin-invert-image
width	200px
pregnancy_AU
pregnancy_US
legal_AU
legal_CA	Schedule I
legal_UK	Class A
legal_US	Schedule I
CAS_number	1474-34-6
UNII_Ref
UNII	MG6JW60TUG
ATC_prefix	none
PubChem	62278
DrugBank_Ref
ChemSpiderID_Ref
ChemSpiderID	21106268
C	20	H=26	N=2	O=2	S=1
smiles	CCC(=O)N(c1ccccc1)C2CCN(CC2)CC(c3cccs3)O
StdInChI_Ref
StdInChI	1S/C20H26N2O2S/c1-2-20(24)22(16-7-4-3-5-8-16)17-10-12-21(13-11-17)15-18(23)19-9-6-14-25-19/h3-9,14,17-18,23H,2,10-13,15H2,1H3
StdInChIKey_Ref
StdInChIKey	GLAAETOTOUGGSB-UHFFFAOYSA-N

| elimination_half-life =

β-Hydroxythiofentanyl (beta-hydroxythiofentanyl) is an opioid analgesic that is an analog of fentanyl and thiofentanyl.

β-Hydroxythiofentanyl was sold briefly on the black market from around 1985, before the introduction of the Federal Analog Act in 1986 which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared. β-hydroxythiofentanyl was anecdotally said to be one of the more favored fentanyl analogs by opiate addicts.

Side Effects

β-Hydroxythiofentanyl has effects and side effects similar to fentanyl. Side effects of fentanyl analogs include itching, nausea and potentially serious respiratory depression, which can be life-threatening.

Legal status

As of October 2015, β-hydroxythiofentanyl is a controlled substance in China.

As of May 2016, β-hydroxythiofentanyl was temporarily listed as a Schedule I controlled substance in the United States. A final ruling placing it in Schedule I was issued by the DEA on May 8, 2019 after a 1 year notice of proposed permanent scheduling. There were no petitions for hearings on the matter.

References

Valter K, Arrizabalaga P. Designer Drugs Directory (1998), p150. {{ISBN. 0-444-20525-X
(March 1988). "Designer drugs: past history and future prospects". Journal of Forensic Sciences.
(November 2025). "In vitro and in vivo pharmacological characterization of fentanyl analogs". Neuropharmacology.
(27 September 2015). "关于印发《非药用类麻醉药品和精神药品列管办法》的通知". China Food and Drug Administration.
(12 May 2016). "Schedules of Controlled Substances: Temporary Placement of Butyryl Fentanyl and Beta-Hydroxythiofentanyl into Schedule I". [[Drug Enforcement Administration]].
{{USC. 5. 556-557
(May 8, 2019). "Schedules of Controlled Substances: Placement of beta-Hydroxythiofentanyl in Schedule I". Department of Justice.
{{CodeFedReg. 21. 1308. 11. 17

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synthetic-opioids thiophenes piperidines secondary-alcohols propionamides anilides mu-opioid-receptor-agonists

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