Α-Methylacetylfentanyl

History

The drug appeared briefly on the black market in the early 1980s, prior to the enactment of the Federal Analog Act, which sought to regulate entire classes of substances based on structural similarity rather than scheduling each one individually as it emerged. Fentanyl analogs have been responsible for hundreds of fatalities across Europe and the former Soviet republics since their re-emergence in Estonia in the early 2000s, and new derivatives continue to appear. In 2013, the Drug Enforcement Administration (DEA) established an aggregate production quota of 2 g for acetyl-alpha-methylfentanyl.

Pharmacology

Pharmacologically, α-methylacetylfentanyl acts as a mu-opioid receptor agonist and produces effects similar to those of fentanyl.

Adverse effects

The adverse effects of fentanyl analogs are also similar to those of fentanyl itself, including itching, nausea, and severe respiratory depression, which may be life-threatening.

Synthesis

α-Methylacetylfentanyl can be synthesized by the same method as α-methylfentanyl, except that the more readily available acetic anhydride is used in place of the less accessible propionic anhydride.

References

References

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8. {{Federal Register. 78. 37238
9. "Acetyl-alpha-methylfentanyl". World Health Organization.
10. "α-Methylacetylfentanyl". DrugBank.