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7-Methyl-α-ethyltryptamine

Chemical compound

13518-76-8 hydrochloride salt | elimination_half-life =

7-Methyl-α-ethyltryptamine (7-Me-αET) is a tryptamine derivative related to α-ethyltryptamine (αET). It was discovered by a team at Upjohn in the early 1960s. It has similar pharmacological effects to αET, but is both 3-4 times more potent as a serotonin releasing agent, and 10 times more potent as a monoamine oxidase inhibitor, making it potentially hazardous as this pharmacological profile is shared with drugs such as PMA and 4-MTA, which are known to be dangerous in humans when used at high doses.

Chemistry

Analogues

Analogues of 7-methyl-AET include α-ethyltryptamine (AET), 4-methyl-AET, 5-fluoro-AET, 5-chloro-AET, 7-chloro-AMT, and 7-methyl-DMT, among others.

References

{{US Patent. 3296072
(May 1964). "Enzyme Inhibitory Activity of 3-(2-Aminobutyl)indole Derivatives". Journal of Medicinal Chemistry.
(July 1966). "Effect of Monase and related compounds on uptake of 5-hydroxytryptamine by platelets". Proceedings of the Society for Experimental Biology and Medicine.

Info: Wikipedia Source

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alpha-alkyltryptamines monoamine-oxidase-inhibitors serotonin-receptor-agonists serotonin-norepinephrine-dopamine-releasing-agents

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