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5β-Reductase

Class of enzymes

Class of enzymes

FieldValue
NameΔ4-3-Oxosteroid 5β-reductase
EC_number1.3.1.3
CAS_number2604034

5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase.

This enzyme catalyses the following general chemical reaction:

:5β-cholestan-3-one + NADP+ \rightleftharpoons cholest-4-en-3-one + NADPH + H+

For example, it interconverts 5β-dihydrocortisone and cortisone:

The human enzyme efficiently acts on progesterone, 17α-hydroxyprogesterone, androstenedione, and testosterone to transform them into 5β-reduced metabolites. It can also act on aldosterone, corticosterone, and cortisol.

References

References

  1. (November 1956). "Separation of delta 4-5 alpha-hydrogenases from rat liver homogenates". The Journal of Biological Chemistry.
  2. (May 1960). "The delta4-hydrogenases of guinea pig adrenal gland". The Journal of Biological Chemistry.
  3. Levy, H.R.. (1957). "Enzymatic introduction of double bonds into steroid ring A". J. Am. Chem. Soc..
  4. (March 1957). "The enzymatic reduction of delta 4-3-ketosteroids". The Journal of Biological Chemistry.
  5. (December 1990). "Purification of 5 beta-reductase from hepatic cytosol fraction of chicken". The Journal of Steroid Biochemistry and Molecular Biology.
  6. (June 1984). "Purification and characterization of delta 4-3-ketosteroid 5 beta-reductase". The Journal of Biological Chemistry.
  7. (January 2001). "Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.
  8. (January 1994). "Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme". European Journal of Biochemistry.
  9. {{KEGG enzyme. 1.3.1.3
  10. (March 1987). "Identification of cortisone 5 beta-reductase as delta 4-3-ketosteroid 5 beta-reductase". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology.
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