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5'-Guanylyl imidodiphosphate

Guanylyl imidodiphosphate 5-Guanylylimidodiphosphate 5′-Guanylyliminodiphosphonate

5'-Guanylyl imidodiphosphate (GDPNP) is a purine nucleotide. It is an analog of guanosine triphosphate in which one of the oxygen atoms is replaced with an amine, producing a non-hydrolyzable functional group. Guanylyl imidodiphosphate binds tightly to G-proteins in the presence of Mg2+. Guanylyl imidodiphosphate is a potent stimulator of adenylate cyclase. It is often used in studies of protein synthesis.

References

[http://www.sigmaaldrich.com/catalog/product/sigma/g0635?lang=en&region=US Guanosine 5′-β,γ-imidotriphosphate trisodium salt hydrate] at [[Sigma-Aldrich]]
[https://pubchem.ncbi.nlm.nih.gov/compound/36735 Guanylyl imidodiphosphate] at [[PubChem]]
Miller, J.D.. (1993). "Ciba Foundation Symposium 176 - the GTPase Superfamily". Ciba Foundation Symposium.
Connolly, T.. (1991). "Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor". Science.

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nucleotides purines organophosphates

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