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3,3'-Diindolylmethane

Chemical compound

Chemical compound

3,3′-Methylenebis-1H-indole DIM

3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale. It and its parent compound indole-3-carbinol are under laboratory research to determine their possible biological properties, particularly in anti-cancer mechanisms. DIM is sold as a dietary supplement.

Properties

In vitro, DIM has action as a histone deacetylase inhibitor, DIM is a metabolite of indole-3-carbinol.

DIM was found to be a mild cannabinoid agonist with low binding affinity for both CB1 and CB2.

A study conducted in 2023 by researchers from Ben-Gurion University of the Negev, in collaboration with teams from Sichuan University and the National University of Singapore, found that DIM can reduce biofilms responsible for dental plaque and cavities by 90%. , no clinical trials have been conducted that confirm the effectiveness of DIM in reducing plaque.

References

References

  1. (1 July 2017). "Indole-3-carbinol". Micronutrient Information Center, Linus Pauling Institute, Oregon State University.
  2. (9 July 2022). "3,3'-Diindolylmethane". PubChem, US National Library of Medicine.
  3. "DIM".
  4. Andhika B. Mahardhika. (March 2023). "Design, synthesis, and structure–activity relationships of diindolylmethane derivatives as cannabinoid CB2 receptor agonists". Archiv der Pharmazie.
  5. Paolo Tucci. (2023). "The Plant Derived 3-3′-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models". International Journal of Molecular Sciences.
  6. Yifat Baruch. (6 June 2023). "3,3′-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic ''Streptococcus mutans'' Biofilm". Antibiotics.
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indoles antineoplastic-drugs histone-deacetylase-inhibitors
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