TLE1

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Protein-coding gene in the species Homo sapiens

title: "TLE1" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public description: "Protein-coding gene in the species Homo sapiens" topic_path: "uncategorized" source: "https://en.wikipedia.org/wiki/TLE1" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Protein-coding gene in the species Homo sapiens ::

Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.

Interactions

TLE1 has been shown to interact with:

References

References

  1. (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry.
  2. (Jan 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics.
  3. "Entrez Gene: TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)".
  4. (Mar 2002). "The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain". Molecular and Cellular Biochemistry.
  5. (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". The Journal of Cell Biology.
  6. (Sep 1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proceedings of the National Academy of Sciences of the United States of America.
  7. (Jan 2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development.
  8. (Dec 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". European Journal of Biochemistry.
  9. (Jan 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal.

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