Temoporfin

Quality 0.50 · 1 view · Updated 2 months ago

Chemical compound

title: "Temoporfin" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["photosensitizing-agents", "tetrapyrroles"] description: "Chemical compound" topic_path: "general/photosensitizing-agents" source: "https://en.wikipedia.org/wiki/Temoporfin" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Chemical compound ::

| verifiedrevid = 448134770 | IUPAC_name = 3,3',3'',3'''-(2,3-dihydroporphyrin-5,10,15,20-tetrayl)tetraphenol | image = Temoporfin.png | image_class = skin-invert-image

| tradename = | Drugs.com = | licence_EU = yes | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration =

| bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion =

| CAS_number_Ref = | CAS_number = 122341-38-2 | ATC_prefix = L01 | ATC_suffix = XD05 | ATC_supplemental = | PubChem = 60751 | DrugBank_Ref = | DrugBank = | ChEMBL = 383675 | UNII_Ref = | UNII = FU21S769PF | KEGG_Ref = | KEGG = D06066 | ChemSpiderID = 54754

| chemical_formula = | C=44 | H=32 | N=4 | O=4 | smiles = C1CC2=NC1=C(C3=CC=C(N3)C(=C4C=CC(=N4)C(=C5C=CC(=C2C6=CC(=CC=C6)O)N5)C7=CC(=CC=C7)O)C8=CC(=CC=C8)O)C9=CC(=CC=C9)O | StdInChI = 1S/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2/b41-33-,41-34-,42-35-,42-37-,43-36-,43-38-,44-39-,44-40- | StdInChIKey = LYPFDBRUNKHDGX-LWQDQPMZSA-N

Temoporfin (INN) is a photosensitizer (based on chlorin) used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck. It is marketed in the European Union under the brand name Foscan. The U.S. Food and Drug Administration (FDA) declined to approve Foscan in 2000. The EU approved its use in June 2001.

Good results were obtained in 21 of 35 patients treated in Germany.

It is photoactivated at 652 nm by red light.

Patients can remain photosensitive for several weeks after treatment.

References

References

  1. (April 2008). "[Squamous cell carcinoma of the head and neck. Photodynamic therapy with Foscan]". Hno.
  2. "Foscan approval saves Scotia's skin.". HighBeam.
  3. (December 2009). "Photodynamic therapy with meta-tetrahydroxyphenylchlorin (Foscan) in the management of squamous cell carcinoma of the head and neck: experience with 35 patients". European Archives of Oto-Rhino-Laryngology.

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::

photosensitizing-agentstetrapyrroles